How a low-calorie diet could extend lifespan

(American Chemical Society) Overeating can lead to health issues that can shorten one's life, such as obesity, diabetes and heart disease. On the other end of the spectrum, several studies have shown that restricting calorie intake below what a normal diet would dictate may lead to a longer life. In an animal study, scientists now report in ACS' Journal of Proteome Research the metabolic reasons why these opposite diets may lead to such differences in longevity.